Aloe vera has been used for medicinal purposes in several cultures for millennia: Greece, Egypt, India, Mexico, Japan, and China. There is broad list of the therapeutic claims of different parts of Aloe vera due to its Pharmacological activities which are employed in traditional management of diverse veterinary and human diseases.  The herb is used internally to combat most digestive problems, including constipation, poor appetite, colitis, irritable bowel syndrome as well as, asthma, diabetes, immune system enhancement and peptic ulcers. A. vera is a succulent plant. Succulents are xerophytes, Storage tissue has higher water holding capacity ranging from 99–99.5% and 0.5–1.0% solid material has over 75 different potentially active compounds including water and fat-soluble vita-mins, minerals, enzymes, simple and complex polysaccharides, phenolic compounds, and organic acids. A. vera gel polysaccharides consist of linear chains of glucose and concentrated mannose molecules, there arrangement linear chains ranging in size from a few to several thou-sand molecules. Different Aloe species would have varying phytochemical contents due to interspecies variation and varying climate and soil conditions, the species of Aloe selected for commercial exploitation or selected by the traditional healer, would be based on its local availability and distribution. A. ferox contains various combinations of glucose and galactose as main monosaccharides, while A. vera yields only mannose. A. vera is rich in secondary metabolites. Anthraquinones (Aloe emodin), tricyclic aromatic quinines and chrysophanol are the major secondary metabolites. Aloe is used against skin irritation, skin exposure to UV and gamma radiation, scalds, sunburn wounds, eczema, psoriasis, acne, dermatitis, ulcers, to stimulate cell regeneration. Plants have hypoglycemic, cytotoxic, antiulcer, antidiabetic effects, antibacterial, antioxidant, cardiovascular effect on human. Healing properties, anti-inflammatory, antiviral and antitumor, moisturizing, anti-aging effect, antiseptic properties of plant stimulates the immune system, only a few species of Aloe have been considered for commercial importance, of which A.  vera is considered the most potent and, thereby, the most popular plant in the research field. The leaf is long triangular sheaf with two external membranes which are green and leathery. Inside this tough resistant covering is the gel, which presents itself as a compact, gelatinous mass with a translucent pearly aspect. Leaf pulp having unpleasant sensations was used to extract the juice by a decortications process. It contains some active compounds which detoxified the body stimulating property worthy of highlighting. The nutritional components of Aloe are equally distributed between the pulp and the cortex of the leaf. Chemistry of the plant revealed the presence of more than 200 different biologically active substances including vitamins, minerals, enzymes, sugars, anthraquinones or phenolic com-pounds, lignin, saponins, sterols, amino acids and salicylic acid the wound healing property of Aloe vera gel has been attributed to Mannose-6-phosphate used for first to second degree burns. Wound healing is a dynamic process, occurring in 3 phases. The first phase is inflammation, hyperaemia and leukocyte infiltration. The second phase consists of removal of dead tissue. The third phase of proliferation consists of epithelial regeneration and formation of fibrous tissue. The Aloe gel has been used for the treatment of radiation burns and radiation ulcers, and complete healing has been observed in two radiation burns patients. The Aloe gel gives cooling effect and also acts as a moisturizing agent. It also has role in gerontology and rejuvenation of aging skin. This property of Aloe is because it’s biogenic material. Aloe vera is used as skin tonic in cosmetic industry. It improves joint flexibility and helps in the regeneration of body cells. It strengthens joint muscles, which therefore reduces pain and inflammation in weakened or aged joints.