ClinicShort Communication | DOI: https://doi.org/10.31579/2835-8325/160
Polycystic Liver in Autosomal Dominant Polycystic Kidney Disease
1The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
2Institute of Digestive Disease, China Three Gorges University, Yichang, PR China.
3Department of Gastroenterology, Yichang Central People’s Hospital, Yichang, PR China.
*Corresponding Author: Wei Liu, Institute of Digestive Disease, China Three Gorges University, 8 Daxue Road, Yichang 443000, China
Citation: Han-S. Fang, Wei Liu, (2024), Polycystic Liver in Autosomal Dominant Polycystic Kidney Disease, Clinical Research and Clinical Reports, 7(4); DOI: 10.31579/2835-8325/160
Copyright: © 2025, Wei Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received: 07 April 2025 | Accepted: 18 April 2025 | Published: 25 April 2025
Keywords: female gender; genetic factors; age; pregnancy
Abstract
A 61-year-old man presented for routine health checkup. The patient was asymptomatic. His medical history was autosomal dominant polycystic kidney disease (ADPKD). Laboratory results and urinalysis were unremarkable.
Summary
A 61-year-old man presented for routine health checkup. The patient was asymptomatic. His medical history was autosomal dominant polycystic kidney disease (ADPKD). Laboratory results and urinalysis were unremarkable. Abdominal computed tomography showed innumerable hepatic cysts of different sizes and diffuse small renal cysts (Figure 1A-C). Polycystic liver disease (PCLD) is divided into the isolated form and PCLD associated with ADPKD, relevant to genetic defects including PKD1 and PKD2 mutations, which belongs to a family of hepatic ductal plate malformations with variable presence of other components of biliary dysgenesis.1 PCLD is the most prevalent extrarenal manifestation, which frequently do not compromise liver function but may produce massive hepatomegaly and abdominal discomfort.2 The liver cysts are not present at birth but develop over time as fluid accumulates, which is commonly modulated by genetic factors, age, pregnancy, and female gender.3 When complications occur, such as intracystic hemorrhage, infection, cystadenocarcinoma, biliary obstruction, Budd-Chiari syndrome and post-traumatic rupture, surgical intervention is required. Surgical procedure commonly includes cyst aspiration and sclerosis, transcatheter arterial embolization, and fenestration and hepatic resection. In this patient, cyst complications were not identified and he continues routine outpatient follow-up.
Figure 1: A-C. Abdominal computed tomography reviews.
Footnote
Conflicts of Interest:
The authors have no conflicts of interest to declare.
Ethical Statement:
The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Written informed consent was obtained from the patient for publication of this “GI Image”. Board institutional approval was not required.
Author’s contributions
Collection of data and writing: Han-Sheng Fang.
Manuscript preparation: Han-Sheng Fang.
Final approval of the manuscript: Wei Liu.
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