Background: Occlusal dysesthesia (OD), also known as phantom bite syndrome, is characterized by the subjective sensation of an uncomfortable or “wrong” bite despite the absence of objective occlusal pathology. This scoping review aimed to synthesize the current evidence on the epidemiology, etiology, clinical presentation, diagnosis, and management of OD. Methods: The PubMed, Google Scholar, Scopus, Web of Science, ScienceDirect, and Cochrane Library databases were systematically searched using the terms “phantom bite,” “occlusal dysesthesia,” “occlusal hyperawareness,” “occlusal hypervigilance,” “uncomfortable occlusion,” and “oral cenestopathy.” Studies were screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria (2020), and evidence quality was assessed using the Oxford Center for Evidence-Based Medicine levels of evidence. Results: A total of 20 studies were included (one systematic review, two clinical guidelines, two case-control studies, one retrospective cohort study, two retrospective case series, six case reports, four narrative reviews, one survey, and one theoretical article). OD predominantly affected middle-aged women, with symptom durations often exceeding several years. OD is increasingly believed to be caused by disorderly central sensory processing or maladaptive signal processing rather than by a primary occlusal abnormality, and high rates of psychiatric comorbidities have been reported. Current evidence supports conservative multidisciplinary management approaches, including patient education, cognitive behavioral therapy, and supportive pharmacotherapy and strongly advises against irreversible dental interventions. Conclusions: OD is a complex biopsychosocial condition requiring multidisciplinary care. The current low-quality evidence is primarily obtained from case reports and case series. Therefore, high-quality controlled trials are urgently required to establish evidence-based diagnostic criteria and treatment protocols.

Occlusal dysesthesia (OD), also known as phantom bite syndrome (PBS), is a challenging clinical entity characterized by persistent complaints of an uncomfortable, altered, or “wrong” bite sensation in the absence of objectively verifiable occlusal discrepancies [1,2]. This condition poses significant diagnostic and therapeutic challenges for dental practitioners, as affected patients often undergo multiple unsuccessful dental interventions in pursuit of relief, potentially leading to iatrogenic complications and symptom worsening [3,4]. The terminology used to describe this condition has evolved over time, reflecting changing conceptual understanding. Early studies used terms such as “phantom bite” to emphasize the discrepancy between subjective perception and objective findings [5]. In contrast, contemporary literature increasingly favors “OD” to highlight the abnormal sensory perception underlying the condition [1,6]. Related terms in the literature include “occlusal hyperawareness,” “occlusal neurosis,” “persistent uncomfortable occlusion,” and “oral cenestopathy” [2,7,8]. Historically, OD was often classified as a primary psychiatric disorder, with some authors describing it as a monosymptomatic hypochondriac or delusional condition [9]. However, recent evidence allows a more nuanced understanding, and OD is believed to be caused by disorderly central sensory processing or maladaptive signal processing, with contributions from both neurophysiological and psychological factors [1,10,11]. This paradigm shift has implications for clinical management, emphasizing the importance of conservative multidisciplinary approaches over aggressive dental interventions. Despite growing clinical recognition, OD remains under-researched, with limited epidemiological data and a paucity of high-quality interventional studies [2,6]. The impact of this condition on patients’ quality of life can be substantial, and it is characterized by persistent distress, preoccupation with oral sensations, and multiple visits to various practitioners [12,13]. Considering the complex and often misunderstood nature of OD, comprehensive synthesis of existing evidence is critical to inform clinical practice and identify research gaps. Therefore, this scoping review aimed to systematically map the available literature on OD; synthesize the current knowledge regarding its epidemiology, etiology, clinical features, diagnostic approaches, and management strategies; and provide evidence-based guidance to clinicians encountering this challenging condition. Additionally, this scoping review aimed to assess the quality of available evidence using the Oxford Center for Evidence-Based Medicine (CEBM) levels of evidence and identify gaps in the current knowledge and priorities for future research

2.1.Protocol And Registration:

This scoping review adhered to the Preferred Reporting Items for Systematic Reviews and Meta- Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines [12]. The protocol was prospectively registered with PROSPERO (registration ID CRD420251157506).

2.2.Eligibility Criteria:

Studies reporting the epidemiology, etiology, pathophysiology, clinical presentation, diagnosis, differential diagnosis, or treatment of OD, PBS, occlusal hyperawareness, occlusal hypervigilance, uncomfortable occlusion, or oral cenestopathy were included. Studies published in English or German, or with available English abstracts were included. The search was conducted without date restrictions to capture the full historical development of knowledge regarding this condition. Studies focusing exclusively on general temporomandibular disorders (TMD) without specific reference to OD or PBS, conference abstracts without full-text availability, duplicate publications, and studies without relevance to the core research questions were excluded.

2.3.Information Sources and Search Strategy:

A comprehensive literature search was conducted in October 2025 using the PubMed (MEDLINE), Google Scholar, Scopus, Web of Science, ScienceDirect, and Cochrane Library databases to ensure broad coverage of the available evidence. The following search terms were used individually and in combination using Boolean operators: ("Phantom bite"[Title/Abstract] OR "Occlusal dysesthesia"[Title/Abstract] OR "Occlusal hyperawareness"[Title/Abstract] OR "Occlusal hypervigilance"[Title/Abstract] OR "Uncomfortable occlusion"[Title/Abstract] OR "Oral cenestopathy"[Title/Abstract])

2.4.Selection Process:

The selection process followed the PRISMA guidelines (2020) and consisted of multiple stages. Studies were identified via the initial searches across all databases, and duplicates were removed. Next, two independent reviewers (I.P. and S.G.) screened the titles and abstracts of the identified studies according to the eligibility criteria. Finally, the full texts of articles that passed the initial screening were reviewed to determine the eligibility for inclusion. Disagreements at any stage were resolved through discussion and consensus of all four reviewers.

2.5.Data Collection:

For each included study, the following data were systematically extracted: Bibliographic information (authors, year, title, journal, and Digital Object Identifier), study design and type, sample size (number of participants, cases, or studies reviewed), study population characteristics (age, sex, and demographics), clinical presentation and symptom characteristics, etiological hypotheses and proposed mechanisms, diagnostic criteria and assessment methods, treatment approaches and interventions, outcomes and prognosis, and key findings and conclusions.

2.6.Quality Assessment:

The quality of evidence was assessed using the Oxford CEBM levels of evidence as follows [13]: Level 1: Systematic reviews, meta-analyses, randomized controlled trials

Level 2: Cohort studies, low-quality randomized controlled trials Level 3: Case-control studies

Level 4: Case series, case reports, and poor-quality cohort/case-control studies. Level 5: Expert opinion, mechanism-based reasoning, and clinical guidelines

2.7.Data Synthesis:

Given the heterogeneity of design and predominantly descriptive nature of the included studies, a qualitative narrative synthesis approach was used. The findings were organized thematically according to the review objectives, with a chronological presentation of evidence development, where appropriate, to illustrate the evolution of understanding over time.

3.1.Study Selection:

The PRISMA 2020 flow diagram (Figure 1) illustrates the study selection process.The database searches retrieved a total of 307 studies, including 40, 64, 39, 52, 104 and 8 studies in the PubMed, Scopus, Google Scholar, Web of Science (via web search), ScienceDirect (via web search), and Cochrane Library (via web search) databases, respectively.After merging the database results and removal of duplicates, 40 unique records were screened based on their titles and abstracts. Of these, 8 were excluded (not relevant), and 32 met the criteria for full-text retrieval. Of these, full texts of four reports could not be retrieved; thus, 28 studies were assessed for eligibility. After full-text assessment, eight reports were excluded (wrong focus). Finally, 20 studies were included in the analysis.

Figure 1: PRISMA-based flowchart illustrating the identification, screening, and selection process of the records during the search.

3.2.Study Characteristics:

The 20 studies included one systematic review [2], one theoretical article [14], four narrative reviews [5,6,11,15], two clinical guidelines [1,16], two retrospective case series [7,17], two case-control studies [18,19], one survey [20], one retrospective cohort study [10] and six case reports [3,4,8,21–23]. All studies were published between 2007 and 2025, and the majority were published after 2012, reflecting the growing clinical and research interest in this condition.

3.3.Evidence Quality Distribution (Oxford Cebm):

The evidence was classified as Level 1, 2, 3, 4, and 5 in 0 (0%), 1 (5%) [2], 2 (10%) [18,19], 4 (20%)[7,10,17,20], and 13 (65%), [1,3–6,8,11,14–16,21–23] studies, respectively.

3.4.Synthesis Of Findings:

3.4.1.Terminology And Definitions

The analysis revealed considerable terminological variation in the literature, reflecting evolving conceptual frameworks. “Phantom bite” was among the earliest descriptive terms used in clinical reports and remains common in dental parlance [5,9]. This term emphasizes the phantom-like quality of symptoms that lack objective correlations. However, OD has emerged as the preferred term in recent clinical guidelines and reviews [1,2,6]. This term emphasizes abnormal perception (dysesthesia) rather than suggesting a primary occlusal defect. Related and alternative terms include “Occlusal hyperawareness” or “occlusal hypervigilance” [7], “persistent uncomfortable occlusion” [7], “occlusal neurosis” (historical term), and “oral cenestopathy” (rare).Across studies, OD was consistently defined as a persistent complaint of uncomfortable, altered, or “wrong” bite sensation despite the absence of objectively verifiable occlusal discrepancy, typically lasting months to years [1,2,6]. However, the concept of OD has evolved significantly over time. Early studies (pre-2010) emphasized psychiatric etiologies, with some authors characterizing OD as a monosymptomatic hypochondriac or delusional disorder [9]. Yamaguchi et al. (2007) described “persistent uncomfortable occlusion” and emphasized the heterogeneous clinical presentations and variable treatment responses [7]. Hara et al. (2012) reported the first systematic review, proposed unified diagnostic criteria, and acknowledged multiple etiologies [2]. Subsequently, biopsychosocial models, such as that by Melis and Zawawi (2015), emphasized the contraindications for irreversible dental treatments [6]. Later, the landmark clinical guidelines by Imhoff et al. (2020) reframed OD as a maladaptive sensory or signal-processing disorder rather than a primary occlusal abnormality and recommended conservative multidisciplinary management [1]. Recent reviews by Tu et al. (2021, 2022) and Türp and Hellmann (2023) reinforced the psychosomatic and neurophysiological understanding [5,11,15].

3.4.2.Epidemiology And Demographics

Population-based prevalence and incidence data are missing in the literature. All available epidemiological information is derived from clinic-based case series, practitioner surveys, or systematic reviews of case reports rather than from population studies [2,20]. Nonetheless, consistent demographic patterns emerged in the clinical cohorts. In most case series, the mean age of patients was 50–60 years. Hara et al. (2012) reported a pooled mean age of approximately 51.7 years in the reviewed case reports [2]. Regarding sex distribution, a pronounced female predominance was consistently observed, and Hara et al. (2012) reported a female-to-male ratio of approximately 5.1:1 [2]. This pattern has been consistent across several subsequent reports [7,10,17]. Regarding clinical frequency, although the population prevalence remains unknown, OD appears to be an uncommon but clinically significant condition. A survey of US orthodontists found that approximately 50% were unfamiliar with the term “phantom bite.” However, many reported encountering patients with compatible complaints [20], suggesting under recognition rather than true rarity. OD was characterized by chronic persistence, with many patients reporting a symptom duration of several years, and Hara et al. (2012) reported a mean symptom duration >6 years [2]. Symptoms began after dental procedures or occlusal interventions in approximately 75% of cases [16]; however, spontaneous onset was also reported [7,11].

3.4.3.Clinical Presentation:

The hallmark symptom is a persistent sensation that the bite is “wrong,” uncomfortable, or altered despite normal clinical and radiographic findings [1,2,6]. Patients typically reported a feeling that teeth do not fit together properly, awareness of specific teeth being “too high” or “in the way,” constant preoccupation with occlusal contacts, and inability to find a comfortable bite position. In addition, emotional distress, anxiety, and depression were frequently reported [2,11,12], and patients often exhibited obsessive checking behavior. Moreover, extensive consultation with multiple dental practitioners was common, with patients seeking repeated evaluations and treatments [3,6], and substantial impairments in oral health-related quality of life and general well-being were reported [12,13,17]. Although concurrent TMD has been reported, the signs and symptoms cannot fully explain the occlusal perception in many cases. TMD is typically characterized by pain and functional limitations rather than pure dysesthetic sensations [7,11,17]. Interestingly, several studies have reported high  rates of psychiatric comorbidities, including major depressive, anxiety, somatoform, personality, and psychotic spectrum disorders [4,10,17]. Watanabe et al. (2015) specifically examined psychiatric comorbidities in PBS and reported heterogeneous psychiatric presentations and variable responses to psychopharmacological interventions [17]. Oguchi et al. (2017) reported outcomes in a Japanese cohort of 61 patients with OD managed with psychosomatic-oriented care [10]. Symptom resolution was achieved in 41% of patients, whereas 33% and 21% discontinued treatment (often with persistent complaints) and required referral to other specialties, respectively. Notably, patients who discontinued treatment often had more prominent psychiatric features.

3.4.4.Etiology And Pathophysiology:

The etiology of OD remains incompletely understood, with multiple, sometimes competing, mechanistic hypotheses. Early studies emphasized primary psychiatric etiologies, including monosymptomatic hypochondriasis, delusional disorders, and somatoform disorders [9,10]. Although psychiatric comorbidities are well-documented, contemporary studies generally reject purely psychiatric models in favor of more integrative frameworks [1,17]. Emerging evidence supports the primary role of altered central sensory processing. Imhoff et al. (2020) reported that OD is likely independent of the actual occlusion and probably reflects maladaptive central signal processing or occlusal hypervigilance [1]. Ono et al. (2016) used portable functional near-infrared spectroscopy (fNIRS) to study the prefrontal hemodynamic responses during occlusal interference tasks [18]. Patients with OD showed persistent increases in deoxygenated hemoglobin over the left frontal pole, and deoxygenated hemoglobin levels in channel- 3 could discriminate patients with OD from controls with 92.9?curacy. Furthermore, Umezaki et al. (2019) reported a case in which pharmacological treatment (mirtazapine plus aripiprazole) improved both symptoms and regional cerebral blood flow, supporting central nervous system involvement [23].Munakata et al. (2016) reported that although occlusal recognition thresholds were similar between patients with OD and controls, discomfort thresholds were significantly lower in patients with OD, suggesting a heightened sensitivity to occlusal discomfort [19]. Some authors propose trigeminal neuropathy or altered peripheral sensory input following dental procedures [6], autoimmune or inflammatory processes affecting oral sensory pathways [6], and altered proprioceptive feedback from periodontal mechanoreceptors [14] as peripheral factors associated with OD. However, these peripheral hypotheses are speculative and lack robust empirical support. The current consensus favors a multifactorial biopsychosocial model in which predisposing factors (personality traits and psychiatric vulnerability) interact with precipitating factors (dental procedures and life stressors) to trigger perpetuating factors (central sensitization, maladaptive coping, and iatrogenic interventions) that maintain the condition [1,10,17]

3.4.5.Differential Diagnosis:

An accurate diagnosis of OD requires the systematic exclusion of other conditions that may present with similar complaints, such as dental and occlusal conditions [1,6], including recent dental work with actual iatrogenic occlusal errors and painful dental conditions (pulpitis, periodontitis, or cracked tooth syndrome); temporomandibular disorders, such as myofascial pain and dysfunction, TMJ arthralgia or arthritis, and disc displacement disorders; neurological conditions, such as trigeminal neuralgia or neuropathic pain, burning mouth syndrome, atypical facial pain, or post- traumatic trigeminal neuropathy [6]; primary psychiatric disorders, including somatic symptom disorder, illness anxiety disorder, delusional disorder (somatic type), major depressive disorder with somatic focus, and obsessive-compulsive disorder [9,19]; other oral conditions, such as oral dyskinesia or movement disorders (xerostomia and salivary dysfunction); and altered oral sensation due to medication side effects. However, Imhoff et al. (2020) emphasize that the diagnosis of OD should be based on characteristic features rather than solely on exclusion [1].

 3.4.6.Diagnostic Approaches and Criteria:

Several factors complicate the diagnosis of OD, including lack of validated, standardized diagnostic criteria; overlap with other conditions (TMD or psychiatric disorders); variable clinical presentations; limited clinician awareness and training [20]; and absence of definitive biomarkers or objective tests. Although no universally accepted diagnostic criteria exist, based on a systematic review of case reports [2], Hara et al. (2012) proposed persistent uncomfortable or altered bite sensation, absence of objective occlusal discrepancy on clinical examination, symptom duration >6 months, onset following dental treatment, and presence of psychological distress or psychiatric comorbidity as unified diagnostic criteria. Imhoff et al. (2020) provide similar diagnostic guidance, emphasizing the discrepancy between subjective complaints and objective findings as a cardinal feature [1]. The recommended assessment components include comprehensive history, including detailed symptom characterization, temporal pattern and onset circumstances, history of dental treatment and its effects, impact on daily functioning and quality of life, psychological and psychiatric history, and current medications; thorough clinical examination, including comprehensive oral and dental examination, systematic occlusal assessment (static and dynamic), TMJ and masticatory-muscle evaluation, neurological screening, and documentation of objective findings (or lack thereof); psychological screening, including assessment for depression, anxiety, and somatization; evaluation of illness beliefs and coping strategies; and consideration of formal psychiatric consultation. In addition, emerging research has explored objective tests to aid diagnosis. A study on foil- thickness recognition and discomfort threshold testing reported that discomfort thresholds (but not recognition thresholds) were significantly lower in patients with OD [19]. Thus, the “foil grinding test” may provide a quantitative measure of occlusal perceptual sensitivity. Similarly, Ono et al. (2016) demonstrated that portable fNIRS measurement of prefrontal hemodynamic responses during occlusal interference could discriminate patients with OD from controls with high accuracy [18]. However, this technology is not yet clinically available, and requires validation using larger samples. Furthermore, research-level neuroimaging (cerebral blood flow assessment using functional magnetic resonance imaging) has provided insights into central nervous system involvement [23]. However, the technique is not practical for routine diagnosis.

3.4.7.Treatment Approaches and Management:

The literature consistently emphasizes conservative, multidisciplinary management, involving a general dentist or prosthodontist (for initial assessment and conservative management), psychologist or psychiatrist (for psychological assessment and treatment), orofacial pain specialist (for differential diagnosis and pain management), and physical therapist (in patients with TMD comorbidity).Türp and Hellmann (2023) emphasize that the primary goal should be improving oral health- related quality of life rather than “curing” the occlusal sensation [15], and Kelleher et al. (2017) specifically warned about the “paradox” of patients demanding dental solutions to non-dental problems [4]. Imhoff et al. (2020) provide comprehensive management guidelines [1] comprising patient education, including explanation of the condition as a sensory perception disorder rather than a structural problem, reassurance regarding the absence of dental pathology, discussion of the biopsychosocial nature of symptoms, and setting realistic treatment expectations and avoiding irreversible dental interventions such as occlusal adjustments, extensive restorations, and orthodontic treatments [1,3,6,10] that often fail to provide relief and may worsen symptoms or create iatrogenic complications. In addition, psychological and behavioral interventions are recommended. Among these, cognitive-behavioral therapy (CBT) is recommended as the primary treatment modality [1,6,10] for maladaptive illness beliefs and behaviors and teaches coping strategies and attention redirection. However, evidence is limited to case reports and expert consensus. In addition, counseling and psychoeducation are recommended for addressing distress, managing stress, and improving sleep hygiene and relaxation, and “defocusing” strategies can be used to redirect attention away from occlusal sensations. Although mindfulness-based approaches have been reported, evidence supporting their usefulness is limited. Few case reports and small case series have reported the usefulness of pharmacological treatments, including antidepressants such as selective serotonin reuptake inhibitors, serotonin- norepinephrine reuptake inhibitors, and mirtazapine [23]; antipsychotics and mood stabilizers including low-dose atypical antipsychotics (e.g., aripiprazole) [23] for patients with psychotic features or severe somatization; and anxiolytics such as benzodiazepines (short-term use only, due to dependence risk) and buspirone or pregabalin (limited evidence). However, Watanabe et al. (2015) reported heterogeneous responses to psychopharmacological interventions, emphasizing the need for individualized approaches [17].Although adjunctive dental treatments such as oral appliances/splints may provide temporary relief through “defocusing” effects [1,17], they should be used as supportive measures, and not as the primary treatment owing to the risk of reinforcing maladaptive illness beliefs. Reversible occlusal modifications such as temporary composite additions are generally not recommended [1]. However, they can be used diagnostically but not therapeutically. Regarding treatment outcomes and prognosis, although individual case reports describe successful outcomes with various approaches, the heterogeneity of treatments and lack of controlled studies preclude definitive conclusions regarding efficacy. The largest cohort study by Oguchi et al. (2017) provides the most comprehensive outcome data [10]: 41%, 33%, and 21% of patients achieved resolution with psychosomatic management, discontinued treatment (often with persistent symptoms), and required referral or transfer to other specialties, respectively. Notably, patients with prominent psychiatric features had poorer outcomes. In addition, limited evidence suggests that longer symptom duration before appropriate diagnosis, multiple previous unsuccessful dental interventions, severe psychiatric comorbidities, rigid illness beliefs, and lack of insight into psychosomatic contributions may be associated with poorer outcomes. Conversely, early recognition, appropriate patient education, and timely multidisciplinary referral may improve prognosis [1,10].

3.4.8.Special Considerations And Complications

A recurring theme in the literature is the risk of iatrogenic complications due to inappropriate dental interventions. Watanabe et al. (2021) described cases of “iatrogenic dental progression,” in which repeated dental procedures exacerbated PBS symptoms, particularly in patients with comorbid psychosis [3]. Moreover, several studies suggest that patients may become trapped in cycles of unsuccessful treatment, leading to extensive dental work, financial burdens, and worsening psychological distress [3,6,10], and some patients develop secondary dental pathology from excessive interventions. Kelleher et al. (2017) discussed medicolegal risks for clinicians, noting that patients may pursue complaints or litigation when treatments fail [4]. Therefore, clear documentation, informed consent, and early appropriate referral are essential. Most of the published literature originates from Japan, Europe, and North America. Therefore, cultural factors may influence symptom expression, help-seeking behavior, and treatment acceptability. Moreover, the structure of the healthcare system affects access to multidisciplinary care.

3.5.Summary Of Evidence

Table 1: presents a comprehensive summary of all the included studies organized chronologically, including study characteristics, sample sizes, Oxford levels of evidence, key findings, and conclusions.

Table 1: Characteristics of included studies. Included Studies on Occlusal Dysesthesia and Phantom Bite Syndrome.

4.1.Comparison with Existing Literature:

This scoping review builds upon and extends previous systematic and narrative reviews.

Hara et al. (2012) synthesized the findings in case reports and proposed unified diagnostic criteria [2]. Although our review confirmed their key findings, incorporating research data from the subsequent decade refined our understanding of neurophysiological mechanisms and strengthened evidence for conservative management.Melis and Zawawi (2015) emphasized the contraindication of irreversible treatments [6]. Our review supports this position with additional evidence from subsequent guidelines and cohort studies.Imhoff et al. (2020) published the most comprehensive evidence-based clinical guidelines to date [1]. Our scoping review complements this guideline by systematically mapping the broader literature landscape and assessing the evidence quality using standardized criteria. Tu et al. (2021, 2022) emphasized the psychosomatic nature of OD and multidisciplinary care needs [5,11]. Our review integrates these perspectives into a comprehensive evidence synthesis.

4.2.Clinical Implications:

The findings in this review have several important clinical implications. General dentists and specialists should be aware of the characteristic presentation of OD to avoid diagnostic delays and inappropriate interventions. Key red flags include persistent occlusal complaints without objective findings, history of multiple unsuccessful dental treatments, psychological distress and preoccupation with occlusion, and repeated requests for occlusal adjustments.

Patients with OD often strongly believe that dental interventions will resolve their symptoms. Clinicians must resist this pressure and educate patients about the true nature of the condition [1,10]. In addition to dental examination, assessment should include psychological screening and consideration of psychosocial factors [11,17]. Moreover, dentists should develop relationships with psychologists, psychiatrists, and orofacial pain specialists to facilitate appropriate referrals [15]. Furthermore, considering the medicolegal risks, careful documentation of findings, patient education, and treatment rationale are essential [4]. Mental health professionals, including psychologists and psychiatrists, should be aware that persistent occlusal complaints may represent specific somatic symptom presentations that require specialized management and that effective management requires close collaboration between mental-health and dental professionals to address both somatic and psychological dimensions. Particularly, CBT and other psychological treatments should be adapted to address the specific cognitive and behavioral patterns characteristic of OD. Regarding healthcare systems and education, dental and medical curricula should include training on OD to improve recognition and appropriate management [20]. Additionally, healthcare systems should establish clear diagnostic and referral pathways for patients with persistent somatic symptoms affecting the oral cavity. Where feasible, specialized clinics integrating dental, psychological, and medical expertise may optimize the care for complex cases.

4.3.Pathophysiological Insights and Future Directions:

Recent neurophysiological studies provide intriguing insights into potential mechanisms that align with the broader pain neuroscience concepts of central sensitization and altered pain modulation. Our findings suggest that OD shares conceptual similarities with other conditions characterized by persistent somatic symptoms without a clear peripheral pathology, such as chronic pain conditions (fibromyalgia and irritable bowel syndrome), functional neurological disorders, persistent postural-perceptual dizziness, and tinnitus. Insights from these fields, particularly regarding central sensitization, predictive coding, and aberrant salience attribution, may inform future research on OD.

4.4.Research Gaps and Future Priorities:

This scoping review identified substantial gaps in the current knowledge regarding OD. First, no population-based prevalence or incidence data were available. Therefore, large-scale epidemiological studies are required to determine the true prevalence in general and clinical populations, incidence rates and natural history, risk factors for development and persistence, and economic burden and healthcare utilization patterns. Second, prospective cohorts with extended follow-up are required to clarify the natural history and spontaneous remission rates, prognostic factors, and long-term outcomes of different management approaches. Third, larger, well-controlled neuroimaging studies using functional magnetic resonance imaging, positron emission tomography, or advanced fNIRS are required to validate and extend the preliminary findings, identify the specific neural circuits and neurotransmitter systems involved, and develop potential biomarkers for diagnosis or treatment response prediction. In addition, psychophysical studies with comprehensive sensory testing protocols are required to characterize the full spectrum of perceptual alterations, distinguish OD from related conditions, and provide quantitative outcome measures for treatment trials. Furthermore, investigation of potential genetic susceptibility factors and molecular mechanisms can inform personalized treatment approaches. Regarding diagnostic research needs, the proposed diagnostic criteria [1,2] must be validated using prospective clinical studies involving diverse populations. Furthermore, development of standardized assessment tools, such as validated questionnaires and clinical assessment protocols, would facilitate consistent diagnosis across settings, severity quantification, and treatment outcome measurement. Similarly, further development and validation of objective tests (fNIRS and sensory thresholds) could improve diagnostic accuracy, reduce diagnostic delay, and provide mechanistic insights To assess treatment efficacy, high-quality randomized controlled trials focusing on psychological interventions (CBT, acceptance and commitment therapy, and mindfulness), pharmacological treatments (antidepressants, antipsychotics, and neuromodulators), combined approaches, and novel interventions based on mechanistic understanding are urgently required. Particularly, studies comparing different management strategies would inform optimal treatment algorithms, and studies elucidating effective treatments can guide the development of more targeted interventions. Finally, studies evaluating whether early intervention after dental procedures can prevent OD development in at-risk individuals are warranted. Regarding health services research needs, studied on effective implementation of evidence- based management in real-world clinical settings are required. In addition, studies evaluating the efficacy of educational interventions for improving clinicians’ recognition and management of OD are required. Finally, studies evaluating the cost-effectiveness of different management approaches are required to inform healthcare policies and resource allocation.

4.5.Strengths And Limitations

4.5.1.Strengths

This study adopted a comprehensive search strategy in which multiple databases were searched using systematic methods following PRISMA guidelines (2020). Moreover, the scoping review approach allowed the inclusion of diverse study types and provided a comprehensive overview of the literature landscape, and the systematic application of Oxford CEBM levels of evidence provided a transparent evaluation of evidence quality. Furthermore, the incorporation of the recent German guidelines [1] ensured the inclusion of the most current expert consensus. Finally, organizing evidence chronologically illuminated the evolution of understanding over time.

4.6.2. Limitations:

Although studies published in the English and German languages were included, relevant literature in other languages (particularly Japanese, given the substantial Japanese contributions to this field) may have been missed. Moreover, grey literature, such as conference abstracts and unpublished studies was not systematically searched, potentially introducing publication bias. In addition, historical variations in terminology may have resulted in some relevant studies being missed despite comprehensive search terms. Furthermore, substantial heterogeneity in the study design, population, and outcome measures precluded a quantitative synthesis, and the predominance of low-level evidence (case reports and series) limited the confidence in many findings.

OD is a complex biopsychosocial condition characterized by persistent uncomfortable bite sensations without an objective occlusal pathology. This scoping review revealed that, although clinical recognition has improved and conceptual understanding has evolved toward neurophysiological and biopsychosocial models, the majority evidence is low-level.

The Key Conclusions Are as Follows:

1. OD is a distinct clinical entity with the following characteristic features: female predominance, onset in middle age, chronic course, onset often following dental procedures, and frequent psychiatric comorbidities.
2. Current evidence suggests that OD is a central sensory processing disorder rather than a primary occlusal or purely psychiatric condition, although psychiatric comorbidities are common and clinically important.
3. Conservative multidisciplinary management is strongly recommended, including patient education, CBT, and supportive pharmacotherapy. Irreversible dental interventions should be avoided because of the risk of iatrogenic harm.
4. Emerging neurophysiological evidence (fNIRS and cerebral blood flow studies) provides objective support for central nervous system involvement and may eventually yield diagnostic biomarkers.
5. Substantial research gaps exist, particularly the absence of population-based epidemiological data, validated diagnostic criteria, and randomized controlled trials.
6. Improved professional education and clinical awareness are needed to facilitate the early recognition, appropriate management, and prevention of iatrogenic complications.

Future research should include population-based epidemiological studies, mechanistic neuroimaging investigations, studies focusing on the development and validation of diagnostic criteria and assessment tools, and high-quality randomized controlled trials focusing on psychological and pharmacological interventions. Such research is essential to establish evidence- based standards of care for this challenging condition. For clinicians encountering patients with persistent uncomfortable bite sensations, the key message is clear: recognize the condition early, resist pressure for dental solutions for what is fundamentally a disorder of sensory perception and processing, educate patients about the true nature of their symptoms, and facilitate timely multidisciplinary care to optimize outcomes and prevent iatrogenic harm.

All four authors equally contributed to every aspect of the study, including conceptualization, methodology, formal analysis, investigation, data curation, writing—original draft preparation, writing—review and editing, visualization, and supervision. All authors have read and agreed to the published version of the manuscript.

 This study did not receive any external funding.

 Not applicable.

 Not applicable.

The data presented in this study are available upon request from the corresponding author.

We would like to thank Editage (www.editage.com) for English language editing.

The authors declare no conflicts of interest.

The following abbreviations are used in this manuscript: